Leptin Resistance Resolution is the physiological and clinical achievement of restoring normal cellular sensitivity to the satiety-regulating hormone leptin, which is primarily secreted by adipose tissue. In a state of resistance, high leptin levels fail to signal satiety and energy sufficiency to the hypothalamus, contributing to persistent hunger and weight gain. Resolution involves interventions that restore the integrity of the leptin signaling pathway, allowing the body to correctly perceive its energy stores.
Origin
The term is rooted in the discovery of leptin in 1994 and the subsequent realization that obesity is often characterized by high circulating leptin levels coupled with a lack of biological response, similar to insulin resistance. “Resolution” describes the reversal of this pathological state, which is a critical goal in metabolic health.
Mechanism
Resolution typically involves reducing chronic systemic inflammation, which is known to impair leptin transport across the blood-brain barrier and interfere with post-receptor signaling within hypothalamic neurons. Interventions such as specific dietary changes, increased physical activity, and pharmacological agents work to decrease the inflammatory burden and restore the sensitivity of the leptin receptor, thereby re-establishing effective satiety signaling.
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