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Leptin Receptor (LEPR)

Meaning

The Leptin Receptor, officially abbreviated as LEPR, is a transmembrane protein primarily expressed on the surface of neurons in the hypothalamus and on various peripheral cells, serving as the essential cellular docking site for the adipokine hormone leptin. Its function is absolutely crucial for sensing the body’s long-term energy stores and precisely regulating appetite, energy expenditure, and overall metabolic rate. The functional integrity and signaling capacity of LEPR are central to maintaining a healthy body weight and preventing conditions like leptin resistance.