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Leptin Ghrelin Regulation

Meaning

Leptin ghrelin regulation describes the dynamic, opposing interplay between the two key peripheral hormones, leptin and ghrelin, that govern appetite, energy balance, and body weight homeostasis. Leptin, secreted by adipose tissue, signals satiety and long-term energy sufficiency, while ghrelin, secreted primarily by the stomach, acts as a potent orexigenic signal, stimulating hunger. The balanced function of this regulatory axis is fundamental to maintaining a stable metabolic set point.