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Leptin Ghrelin

Meaning

Leptin and Ghrelin are two distinct, critically important peptide hormones that serve as primary, antagonistic regulators of energy balance, appetite, and satiety through their action on the hypothalamus. Leptin, secreted proportionally by adipocytes, signals long-term energy sufficiency and suppresses appetite, while Ghrelin, predominantly secreted by the stomach, signals acute hunger and initiates food-seeking behavior. The delicate, reciprocal balance between these two hormones is fundamental to metabolic homeostasis and the long-term regulation of body weight.