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Least Significant Change

Meaning

The Least Significant Change (LSC) is a statistical metric used in clinical measurement, most notably in bone mineral density testing (DXA), to quantify the minimum amount of change in a patient’s measured value that can be confidently considered a true biological effect rather than simple random measurement variability. Clinicians rely on the LSC to accurately interpret serial measurements, ensuring that treatment decisions are based on genuine progression or improvement, not just measurement noise. It is a vital tool for monitoring the effectiveness of hormonal therapies aimed at bone preservation.