Lean Tissue Accrual is the process of increasing metabolically active muscle mass, distinct from adipose tissue accumulation, through effective anabolism. This process is fundamental to maintaining basal metabolic rate and improving insulin sensitivity throughout the lifespan. It is a direct outcome of anabolic hormone sufficiency and adequate nutritional input.
Origin
This term is derived from physiology, where “Lean Tissue” refers to everything except body fat, and “Accrual” means accumulation. In endocrinology, this concept is intrinsically linked to the anabolic effects of growth hormone and testosterone signaling pathways. We are measuring positive structural adaptation.
Mechanism
Accrual is driven by mechanical loading (resistance exercise) signaling muscle protein synthesis via the mTOR pathway. This pathway is highly responsive to insulin and amino acid availability. Sufficient anabolic hormone support ensures that the signaling cascade remains robust, allowing for efficient incorporation of substrates into myofibrillar structures.
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