Lean Tissue Accretion signifies the net accumulation of metabolically active mass, primarily skeletal muscle and bone mineral, within the body over time. This process is fundamental to maintaining robust metabolic health and physical function, particularly as individuals age. We prioritize this accretion as it improves glucose disposal capacity and basal energy expenditure. Achieving positive accretion requires a sustained anabolic stimulus exceeding catabolic processes.
Origin
This term is drawn from body composition analysis and sports science, used to precisely quantify positive changes in non-adipose mass. It moves beyond simple weight gain to specify the desirable quality of the added tissue. The origin is rooted in quantitative physiology.
Mechanism
Accretion is mechanistically driven by sufficient systemic amino acid availability coupled with potent anabolic signaling, primarily mediated by the Insulin-like Growth Factor 1 (IGF-1) axis downstream of growth hormone release. Resistance training provides the necessary mechanical tension, while appropriate nutrient timing ensures the cellular machinery for protein synthesis is maximally supported. This coordinated response leads to myofibrillar hypertrophy and structural gains.
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