Lean Muscle Mass Accrual signifies the net increase in skeletal muscle tissue, excluding fat mass, achieved over a period, typically through resistance training and adequate nutritional support. From an endocrinological perspective, this process relies heavily on anabolic signaling pathways mediated by growth factors and sex steroids. Optimizing this accrual is a primary goal in sarcopenia prevention and performance enhancement.
Origin
This term blends physiological measurement (‘lean mass’) with the biological process of building tissue (‘accrual’), rooted in muscle biology and hypertrophy studies. It focuses specifically on the deposition of contractile proteins.
Mechanism
Accrual is driven primarily by anabolic hormones such as testosterone and growth hormone, which stimulate muscle protein synthesis exceeding muscle protein breakdown. Resistance exercise provides the necessary mechanical tension stimulus, activating the $text{PI}3text{K}/text{Akt}/text{mTOR}$ signaling cascade within the muscle fibers. Sufficient amino acid availability must also be present to support the increased demands of new myofibrillar protein assembly.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.