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Lean Muscle Mass Accretion

Meaning

Lean Muscle Mass Accretion describes the physiological process of increasing the non-fat component of the body, specifically skeletal muscle tissue, through net positive protein balance exceeding catabolism. This process is critically dependent on anabolic signaling pathways mediated by hormones such as insulin-like growth factor 1 (IGF-1) and testosterone. Optimizing accretion is a key clinical goal in addressing sarcopenia and improving basal metabolic rate regulation. Suboptimal accretion often signals an underlying deficit in anabolic hormone support or nutrient availability.