What is the Origin of Lean Mass Retention Protocols?

The protocols derive from exercise physiology and geriatric endocrinology, where the failure to maintain muscle mass significantly correlates with reduced physical capacity and increased morbidity. The term emphasizes 'retention' as the goal, recognizing the body's inherent catabolic tendencies with advancing age.

What is the Mechanism of Lean Mass Retention Protocols?

The primary mechanism involves leveraging anabolic hormones, such as optimized testosterone or growth hormone signaling, in conjunction with adequate amino acid substrate delivery, particularly leucine. Resistance training provides the necessary mechanical tension to upregulate mTOR signaling pathways within myocytes. This synergy promotes a positive net protein balance, thereby preserving or increasing myofibrillar protein content.

Lean Mass Retention Protocols ∞ Area

Lean Mass Retention Protocols

Meaning

These are structured, evidence-based clinical strategies designed specifically to mitigate age-related or catabolic losses of skeletal muscle mass, or sarcopenia, by optimizing anabolic signaling environments. Protocols integrate resistance exercise stimulus with precise nutritional timing and endocrine support to maximize muscle protein synthesis rates. Maintaining sarcoplasmic integrity is a primary clinical goal.