What is the Origin of Lean Mass Homeostasis?

Originating from physiology, 'homeostasis' refers to the tendency toward a relatively stable equilibrium, applied here specifically to 'lean mass' (non-fat body composition). This concept acknowledges that stability is achieved through constant, active physiological regulation.

What is the Mechanism of Lean Mass Homeostasis?

Homeostasis is governed by the interplay of anabolic hormones, such as testosterone and insulin, which promote muscle protein synthesis, and catabolic signals, including chronic cortisol and systemic inflammation, which promote breakdown. Adequate mechanical loading provides the necessary stimulus to maintain muscle fiber responsiveness to anabolic hormones. When the balance tips toward catabolism, mechanisms like increased ubiquitin-proteasome pathway activity accelerate tissue degradation.

Lean Mass Homeostasis ∞ Area

Lean Mass Homeostasis

Meaning

Lean Mass Homeostasis describes the dynamic equilibrium maintained by the body regarding skeletal muscle and organ mass, balancing protein synthesis and protein breakdown within narrow physiological limits. In a healthy state, this balance supports functional integrity and metabolic efficiency. Disruption, often seen in catabolic states, leads to a net loss of functional tissue mass. Maintaining this equilibrium is central to long-term vitality.