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LDL Receptor Upregulation

Meaning

LDL Receptor Upregulation is a crucial homeostatic mechanism where the number of Low-Density Lipoprotein (LDL) receptors expressed on the surface of hepatic and peripheral cells increases. This biological action enhances the clearance of circulating LDL-cholesterol particles from the bloodstream, thereby playing a pivotal role in maintaining plasma lipid homeostasis and reducing cardiovascular risk. In the context of hormonal health, robust upregulation is essential because cholesterol is the obligatory precursor for all steroid hormones, including cortisol, testosterone, and estrogen. Therefore, efficient receptor function ensures adequate substrate delivery for steroidogenesis while preventing hypercholesterolemia.