Question 1

What is the Meaning of LC-MSMS?

Accepted Answer

LC-MS/MS, or Liquid Chromatography-Tandem Mass Spectrometry, is a highly sensitive and specific analytical technique used in clinical laboratories to accurately identify and quantify small molecules, such as hormones, metabolites, and therapeutic drugs, in biological samples. This method is considered the gold standard for measuring low-concentration steroid hormones, offering superior precision and minimizing cross-reactivity compared to older immunoassay techniques.

Question 2

What is the Origin of LC-MSMS?

Accepted Answer

The term is an acronym for the combination of two distinct analytical processes: Liquid Chromatography (LC) and Tandem Mass Spectrometry (MS/MS). The development of this technique emerged from advancements in analytical chemistry, allowing for the simultaneous separation and molecular identification of complex mixtures. Its clinical application revolutionized hormonal testing by providing unparalleled specificity.

Question 3

What is the Mechanism of LC-MSMS?

Accepted Answer

The process begins with the Liquid Chromatography step, which physically separates the various components of the biological sample based on their chemical properties. Subsequently, the separated molecules enter the Tandem Mass Spectrometer, where they are ionized, fragmented, and then measured based on their unique mass-to-charge ratio. This dual-stage mechanism ensures that the target hormone is both isolated from interfering substances and unequivocally identified, yielding highly accurate quantitative results.

LC-MSMS

Meaning

Origin

Mechanism

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