Question 1

What is the Meaning of Lateralization Index?

Accepted Answer

The Lateralization Index (LI) is a critical calculated ratio derived from Adrenal Vein Sampling (AVS) results, which is used to quantify the relative excess of aldosterone secretion between the two adrenal glands. This index is essential for determining if the source of autonomous aldosterone production is predominantly unilateral, a key distinction for guiding definitive surgical treatment. A clear lateralization is the primary indicator for considering adrenalectomy.

Question 2

What is the Origin of Lateralization Index?

Accepted Answer

This is a specialized clinical metric used in the workup for Primary Aldosteronism, where Lateralization refers to the confinement of the hormonal excess to one side of the body. The Index is the mathematical tool used to quantify this asymmetry. It was developed to standardize the interpretation of the technically demanding AVS procedure.

Question 3

What is the Mechanism of Lateralization Index?

Accepted Answer

The index is calculated by comparing the aldosterone-to-cortisol ratio in the high-side adrenal vein sample to the ratio in the low-side adrenal vein sample. Cortisol is used as a normalizing factor to account for the dilution of the sample and to confirm successful selective cannulation of the adrenal vein. A pre-defined cutoff value for the LI, typically three or four to one, is used to confirm the unilateral nature of the aldosterone excess, indicating an Aldosterone-Producing Adenoma or Unilateral Adrenal Hyperplasia.

Lateralization Index

Meaning

Origin

Mechanism

What Clinical Tests Precisely Assess Adrenal Response to Sodium Levels?

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