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Late Onset Hypogonadism LOH

Meaning

Late Onset Hypogonadism (LOH), also commonly referred to as age-related male hypogonadism, is a clinical syndrome characterized by a deficiency in testosterone production that develops progressively with advancing age. This hormonal decline is associated with non-specific, often subtle symptoms, including decreased libido, erectile dysfunction, reduced muscle mass, increased visceral fat, and diminished vitality. The diagnosis is confirmed by consistently low serum testosterone levels in conjunction with these clinical signs. LOH represents a complex endocrine phenomenon distinct from classical hypogonadism, often involving a mix of primary testicular failure and secondary hypothalamic-pituitary dysfunction.