What is the Origin of Late Onset Hypogonadism Diagnosis?

This specific terminology emerged in the field of male endocrinology to distinguish the age-related, gradual decline in gonadal function from congenital or acquired hypogonadism in younger men. The term emphasizes the importance of age as a contributing factor and the need for a comprehensive diagnostic approach that integrates both laboratory values and clinical presentation. It highlights the importance of timely intervention for quality of life and metabolic health.

What is the Mechanism of Late Onset Hypogonadism Diagnosis?

The pathophysiology is complex and multifactorial, often involving a primary component of Leydig cell dysfunction in the testes and a secondary component of reduced GnRH and LH pulsatility from the hypothalamus and pituitary. This dual-axis decline leads to a reduction in total and free testosterone. Diagnosis relies on morning serum total testosterone, and often free testosterone or calculated free testosterone, measured in conjunction with pituitary hormones like LH and FSH to determine the site of failure.

Late Onset Hypogonadism Diagnosis ∞ Area

Late Onset Hypogonadism Diagnosis

Meaning

Late Onset Hypogonadism Diagnosis, often referred to clinically as LOH, is the formal identification of a progressive decline in testicular function and testosterone production in aging men, accompanied by characteristic clinical symptoms. The diagnosis requires both biochemical confirmation of low serum testosterone levels and the presence of associated symptoms, which may include reduced libido, fatigue, decreased muscle mass, and mood disturbances. It is a distinct clinical entity from classical primary or secondary hypogonadism.