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Late-Onset Androgen Deficiency

Meaning

Late-Onset Androgen Deficiency (LOAD) is the clinical syndrome characterized by a significant, symptomatic decline in bioavailable testosterone and other androgens that occurs progressively with advancing age in men, distinct from classical hypogonadism. This condition presents with a constellation of non-specific symptoms, including reduced libido, diminished vitality, decreased muscle mass, increased visceral adiposity, and often impaired mood and cognitive function. Diagnosis requires careful clinical evaluation coupled with laboratory confirmation of consistently low free and total testosterone levels, necessitating a personalized therapeutic approach to restore hormonal vitality.