What is the Origin of L-Glutamine Repair?

The concept originates from clinical nutrition and gastroenterology, recognizing L-glutamine as the primary fuel source for enterocytes and immune cells. 'Repair' underscores its specific role in mitigating damage caused by stress, intense exercise, or inflammatory conditions that compromise mucosal integrity. This amino acid is critical for maintaining mucosal structure and function under catabolic stress.

What is the Mechanism of L-Glutamine Repair?

L-glutamine acts by serving as a key substrate for nucleotide synthesis and as a precursor for the antioxidant glutathione, both essential for cellular proliferation and defense. In the gut, it strengthens the tight junctions between enterocytes, reducing the translocation of harmful substances like endotoxins into the bloodstream. This reparative function directly impacts systemic health and nutrient absorption efficiency.

L-Glutamine Repair ∞ Area

L-Glutamine Repair

Meaning

L-Glutamine Repair refers to the therapeutic utilization of the conditionally essential amino acid L-glutamine to support the regeneration and integrity of rapidly proliferating tissues, most notably the gastrointestinal mucosa and immune cells. Clinically, this intervention is vital for maintaining the intestinal barrier function and reducing systemic inflammation stemming from gut permeability, often referred to as leaky gut. It is a foundational element of recovery and immune support in high-stress states.