Skip to main content

L-Cell Peptide Release

Meaning

L-Cell Peptide Release is the regulated secretion of specific gut hormones, predominantly Glucagon-Like Peptide-1 (GLP-1) and Peptide YY (PYY), from specialized enteroendocrine L-cells located primarily in the distal ileum and colon. This release is a critical component of nutrient sensing, satiety signaling, and postprandial glucose regulation. Manipulating this release pathway is a significant therapeutic target in managing type 2 diabetes and obesity. It represents a key hormonal output from the gut-brain axis.