What is the Origin of Kisspeptin Protocol?

The term originates from the discovery of the KISS1 gene, which encodes the kisspeptin family of proteins, and the subsequent development of defined administration schedules, hence the "Protocol." Kisspeptin's role as the master regulator of puberty and reproductive cycling established its clinical significance. Its name itself is a historical nod to its discovery site, though its function is purely physiological.

What is the Mechanism of Kisspeptin Protocol?

The protocol functions by delivering exogenous kisspeptin, which binds to its cognate receptor (KISS1R) on GnRH-producing neurons in the hypothalamus. This binding powerfully stimulates pulsatile release of Gonadotropin-Releasing Hormone (GnRH). Subsequently, GnRH travels to the pituitary gland, prompting the release of LH and FSH, thereby initiating the downstream cascade of gonadal steroid production. The response kinetics observed during the protocol provide vital diagnostic information.

Kisspeptin Protocol ∞ Area

Kisspeptin Protocol

Meaning

A Kisspeptin Protocol refers to a specific clinical or research regimen involving the administration of kisspeptin peptides, the primary physiological drivers of GnRH release in the hypothalamus. In clinical practice, this protocol is often employed to stimulate or assess the integrity of the Hypothalamic-Pituitary-Gonadal (HPG) axis function. It represents a targeted approach to evaluating reproductive endocrinology potential. This precise stimulation helps differentiate central hypogonadism from peripheral causes.