What is the Origin of Kisspeptin HPG Stimulation?

Kisspeptin was initially discovered as a metastasis suppressor gene in 1996, but its critical role in reproductive endocrinology was established in the early 2000s. The name derives from the Hershey, Pennsylvania, region where the gene was first identified. The term "HPG Stimulation" clearly delineates its primary function as the key upstream activator of the entire reproductive hormone cascade.

What is the Mechanism of Kisspeptin HPG Stimulation?

Kisspeptin binds with high affinity to its cognate receptor, GPR54, which is expressed almost exclusively on GnRH neurons. This binding leads to the depolarization and subsequent pulsatile firing of the GnRH neurons. The resultant release of GnRH then signals the pituitary to release LH and FSH, which travel to the gonads to stimulate sex hormone production. The integrity of Kisspeptin signaling is thus the primary determinant of reproductive hormone status.

Kisspeptin HPG Stimulation ∞ Area

Kisspeptin HPG Stimulation

Meaning

Kisspeptin HPG Stimulation refers to the potent, central action of the neuropeptide Kisspeptin in initiating and driving the Hypothalamic-Pituitary-Gonadal (HPG) axis. Kisspeptin, released from specialized neurons in the hypothalamus, acts directly on GnRH neurons, triggering the pulsatile release of GnRH, which is the master signal for reproductive function. This stimulation is absolutely essential for the onset of puberty and the maintenance of fertility throughout life.