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Kisspeptin GnRH Modulation

Meaning

Kisspeptin GnRH Modulation refers to the therapeutic targeting of the kisspeptin-GPR54 signaling pathway, which is the master regulator of Gonadotropin-Releasing Hormone (GnRH) secretion from the hypothalamus. This precise neurological control is fundamental to the pulsatile release of GnRH, which in turn governs the entire reproductive axis by stimulating the pituitary to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). Clinical modulation is utilized to address various reproductive and hormonal disorders, including pubertal delay, functional hypothalamic amenorrhea, and certain forms of infertility, by restoring the natural rhythm of the hypothalamic-pituitary-gonadal (HPG) axis. This strategy offers a highly specific way to influence sex hormone balance.