What is the Origin of Kisspeptin-10?

The name "Kisspeptin" originated from its discovery site in the KISS1 gene, humorously named after the Hershey's Kisses chocolate, though its function relates to 'Kissing' or initiating the reproductive cascade. The "-10" denotes the specific sequence length of this highly potent signaling fragment. It is a key discovery in modern reproductive endocrinology.

What is the Mechanism of Kisspeptin-10?

Kisspeptin-10 exerts its function by binding to the GPR54 receptor, which is highly expressed on GnRH neurons within the hypothalamus. Activation of this G-protein coupled receptor stimulates intracellular signaling pathways that promote the pulsatile release of GnRH. Consequently, this drives the pituitary to release LH and FSH, ultimately stimulating gonadal steroidogenesis. This pathway represents the master switch controlling puberty and adult reproductive hormone cycling.

Kisspeptin-10 ∞ Area

Kisspeptin-10

Meaning

Kisspeptin-10 ($text{Kp-10}$) is a biologically active decapeptide fragment derived from the full kisspeptin protein, serving as the primary physiological activator of the reproductive axis. This neuropeptide is essential for initiating and maintaining GnRH (Gonadotropin-releasing hormone) secretion from the hypothalamus. Insufficient or dysregulated $text{Kp-10}$ signaling results in hypogonadotropic hypogonadism, highlighting its critical role in gonadal hormone regulation.