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Ketone Body Signaling

Meaning

Ketone Body Signaling is the role of ketone bodies, particularly beta-hydroxybutyrate (βOHB), as critical signaling molecules that communicate metabolic and environmental status to the cell, extending beyond their traditional function as alternative energy substrates. Produced by the liver during states of carbohydrate restriction or fasting, these molecules act as metabolic messengers that influence gene expression, inflammation, and cellular protection. This signaling mechanism represents a powerful, evolutionarily conserved pathway linking nutritional status directly to fundamental processes of healthspan and resilience. Optimizing this signaling is a key focus in metabolic and neurological wellness.