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Ketone Body Oxidation

Meaning

Ketone body oxidation is the biochemical process by which the body’s peripheral tissues, especially the brain and muscle, utilize ketone bodies—acetoacetate and beta-hydroxybutyrate—as an energy source. This metabolic pathway becomes significantly active during periods of carbohydrate restriction, fasting, or prolonged exercise, providing an essential alternative fuel when glucose availability is low. Efficient ketone oxidation is a key marker of metabolic flexibility and supports stable energy for cognitive function.