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Ketone Body Neuroprotection

Meaning

Ketone Body Neuroprotection is the biological phenomenon where ketone bodies, primarily beta-hydroxybutyrate (BHB) and acetoacetate, confer resilience and defense to neuronal cells against various forms of metabolic and oxidative stress. This protective effect extends beyond merely providing an alternative fuel source to the brain during periods of glucose scarcity. Ketone bodies actively modulate signaling pathways that enhance mitochondrial function, reduce inflammation, and promote the expression of survival genes. This mechanism represents a powerful, endogenously regulated strategy for maintaining neural health and cognitive longevity.