What is the Origin of Ketogenic Therapies?

The original therapeutic use of the ketogenic diet dates back to the 1920s for the management of refractory epilepsy, predating the development of modern anticonvulsant medications. The term "ketogenic" is derived from the process of ketogenesis, the metabolic pathway of ketone body production. Its modern application in the hormonal health space is a re-emergence driven by its profound effects on insulin sensitivity and metabolic flexibility.

What is the Mechanism of Ketogenic Therapies?

The severe restriction of dietary carbohydrates depletes hepatic glycogen stores, signaling the body to switch from glucose oxidation to fat oxidation. This sustained fat breakdown, or lipolysis, overwhelms the liver's capacity to process acetyl-CoA through the Krebs cycle, leading to the diversion of acetyl-CoA into the synthesis of ketone bodies. The presence of these ketones provides a stable, efficient fuel source that can bypass the insulin-dependent glucose transport mechanism in the brain.

Ketogenic Therapies ∞ Area

Ketogenic Therapies

Meaning

Ketogenic therapies encompass a range of nutritional interventions characterized by very low carbohydrate intake, moderate protein consumption, and high fat consumption, designed to induce a metabolic state known as ketosis. In this state, the liver produces ketone bodies (beta-hydroxybutyrate, acetoacetate) from fat as an alternative primary fuel source for the brain and body. Clinically, these therapies are utilized for metabolic syndrome management, neurological health support, and weight regulation.