What is the Origin of Ketogenic Neuroprotection?

The concept is rooted in the clinical application of the ketogenic diet, which has historically been used to manage refractory epilepsy. 'Neuroprotection' is a standard term in neuroscience referring to mechanisms that prevent neuronal cell death.

What is the Mechanism of Ketogenic Neuroprotection?

Ketones, particularly BHB, serve as a highly efficient fuel source, bypassing impaired glucose metabolism often seen in aging or disease. BHB also acts as a signaling molecule, directly inhibiting histone deacetylases (HDACs), which promotes the expression of protective genes, including those for antioxidant enzymes. Furthermore, ketone metabolism enhances mitochondrial function, reduces the production of reactive oxygen species, and increases the cellular resilience to excitotoxicity and oxidative stress, all contributing to a more robust neuronal environment.

Ketogenic Neuroprotection

Meaning

Ketogenic Neuroprotection describes the therapeutic effects of a ketogenic metabolic state, characterized by the elevation of circulating ketone bodies, in safeguarding neurons against injury, dysfunction, and degeneration. This protective mechanism is observed across various neurological conditions and is a focus of research in longevity and cognitive health. The utilization of ketones, primarily beta-hydroxybutyrate (BHB), as an alternative fuel source offers significant metabolic advantages to the brain. This strategy aims to enhance neuronal resilience and metabolic efficiency.