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Ketogenic Diet Epigenetics

Meaning

Ketogenic Diet Epigenetics describes the specific influence of a very low-carbohydrate, high-fat diet on gene expression and cellular regulatory mechanisms via the production of ketone bodies, particularly beta-hydroxybutyrate (BHB). This dietary state shifts the body’s primary fuel source, which in turn acts as a potent signaling molecule to modify the epigenome, affecting genes related to longevity, stress resistance, and metabolism. The clinical application leverages this metabolic shift to induce favorable epigenetic changes that can enhance mitochondrial function and reduce oxidative stress. It is a precise nutritional intervention for optimizing genomic health.