Ketogenic describes a metabolic state characterized by the liver’s production of ketone bodies from fatty acids, which are then utilized by the brain and other tissues as an alternative and often more efficient fuel source than glucose. This state is typically induced by a dietary regimen high in fats, very low in carbohydrates, and adequate in protein, clinically known as a ketogenic diet. The resulting shift in substrate utilization profoundly impacts hormonal signaling and cellular energy pathways.
Origin
The concept of ketosis is rooted in biochemistry and was historically applied in clinical neurology for the management of refractory epilepsy, predating its modern use in weight management and metabolic health. Its relevance in the longevity and hormonal health domain stems from the observation that ketone bodies, particularly beta-hydroxybutyrate (BHB), act as signaling molecules that can modulate gene expression and enhance mitochondrial function. This metabolic flexibility is considered a marker of resilience.
Mechanism
The mechanism involves severe restriction of dietary carbohydrates, which depletes liver glycogen stores and lowers circulating insulin levels. This hormonal shift signals the body to initiate lipolysis, releasing fatty acids that are subsequently converted into ketone bodies in the liver via ketogenesis. Ketone bodies can cross the blood-brain barrier and serve as a super-fuel, simultaneously activating longevity pathways like the sirtuins and potentially reducing oxidative stress compared to glucose metabolism.
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