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Keratinocyte Signaling

Meaning

Keratinocyte signaling refers to the complex network of communication pathways and molecular messages exchanged by keratinocytes, the predominant cell type in the epidermis, which are responsible for forming the skin’s protective barrier. This signaling governs crucial processes such as cell proliferation, differentiation, migration, and the initiation of immune and inflammatory responses. The integrity and responsiveness of these signaling pathways are paramount for wound healing, barrier function, and overall skin resilience. Disruptions in this communication contribute to conditions like psoriasis and eczema.