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KEEPS Continuation Study

Meaning

The KEEPS Continuation Study is the long-term, observational follow-up to the original Kronos Early Estrogen Prevention Study, which was a randomized trial investigating the effects of different hormone therapy regimens in recently menopausal women. This continuation phase is vital for gathering extended data on the long-term safety and efficacy of early postmenopausal hormone replacement, particularly concerning critical endpoints like cardiovascular health, bone density, and cognitive function. It provides essential evidence for evidence-based clinical guidelines.