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KEEPS

Meaning

KEEPS stands for the Kronos Early Estrogen Prevention Study, a significant randomized, placebo-controlled clinical trial designed to investigate the effects of early postmenopausal hormone therapy on cardiovascular and cognitive health outcomes. The study specifically examined the impact of two different hormone regimens—oral conjugated equine estrogens and transdermal $17beta$-estradiol—in recently menopausal women. The findings of KEEPS provided essential data regarding the “timing hypothesis” in hormone replacement therapy, emphasizing the importance of initiating treatment early in the menopausal transition.