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KCC2

Meaning

KCC2, or Potassium Chloride Cotransporter 2, is a specific neuronal membrane protein that actively transports potassium and chloride ions out of the cell. This crucial function maintains a low intracellular chloride concentration in mature neurons, which is essential for the inhibitory action of the neurotransmitter GABA. Proper KCC2 function is fundamental for maintaining the excitability balance within the central nervous system.