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Jet Lag Physiology

Meaning

Jet lag physiology describes the array of transient physical and mental symptoms that arise from a mismatch between the body’s intrinsic circadian rhythm, primarily regulated by the suprachiasmatic nucleus, and the external light-dark cycle of a new time zone. This desynchronization of the internal clock and the external environment profoundly affects the rhythmic secretion of key hormones, including cortisol and melatonin, which govern sleep-wake cycles and metabolic processes. Understanding this physiological disruption is crucial for optimizing health during trans-meridian travel.