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JAK2-STAT5B Pathway

Meaning

The JAK2-STAT5B Pathway is a critical intracellular signaling cascade that serves as the primary route for transducing the effects of various peptide hormones and cytokines, most notably Growth Hormone (GH) and prolactin, from the cell surface to the nucleus. This canonical non-receptor tyrosine kinase pathway is essential for regulating fundamental cellular processes including cell proliferation, differentiation, survival, and the transcription of specific metabolic and growth-related genes. In the context of hormonal health, its proper function is paramount for linear growth, hematopoiesis, and the regulation of hepatic metabolism. Dysregulation within this pathway can be implicated in growth disorders and certain endocrine-related malignancies.