What is the Origin of IVF Protocol?

The term combines the abbreviation for In Vitro Fertilization, a medical procedure where fertilization occurs outside the body, with "protocol," a term widely used in medicine to denote a detailed plan or set of rules for a course of treatment. The evolution of IVF protocols began with the first successful IVF birth, continually refining the use of exogenous gonadotropins and GnRH analogues to achieve controlled ovarian hyperstimulation.

What is the Mechanism of IVF Protocol?

The core mechanism of any IVF protocol involves exogenous hormonal control to override the body's natural reproductive cycle. Medications like Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) are administered to stimulate the simultaneous growth of multiple ovarian follicles. A Gonadotropin-Releasing Hormone (GnRH) agonist or antagonist is then used to prevent a premature luteinizing hormone surge, which would cause spontaneous ovulation. Finally, a Human Chorionic Gonadotropin (hCG) trigger shot is administered to mimic the natural LH surge, ensuring the final maturation of the eggs for timed retrieval.

IVF Protocol

Meaning

An IVF protocol refers to the meticulously planned, individualized sequence of medications, monitoring procedures, and timing used to manage a patient undergoing In Vitro Fertilization treatment. This comprehensive regimen is designed to optimize ovarian stimulation, control the timing of ovulation, and maximize the chances of retrieving viable eggs for fertilization. Different protocols, such as the antagonist or agonist approaches, are selected based on the patient’s age, ovarian reserve, and medical history.