What is the Origin of IVF Metabolic Effects?

This clinical term is a modern construct arising from the widespread use of Assisted Reproductive Technology (ART) and the subsequent observation of systemic physiological changes induced by the necessary ovarian stimulation. It connects the acronym IVF with the broader field of Metabolic Effects, highlighting the impact of exogenous gonadotropins and high steroid levels on the body's energy regulation systems.

What is the Mechanism of IVF Metabolic Effects?

The mechanism is largely driven by supraphysiological levels of sex steroids, particularly estrogen and progesterone, which are produced or administered during the ovarian stimulation phase. High estrogen levels can temporarily interfere with insulin signaling pathways, leading to a degree of peripheral insulin resistance and subsequent compensatory hyperinsulinemia. This hormonal shift transiently alters glucose homeostasis and hepatic lipid processing, resulting in the observed metabolic changes.

IVF Metabolic Effects

Meaning

IVF Metabolic Effects refer to the systemic changes in carbohydrate, lipid, and protein metabolism observed in women undergoing In Vitro Fertilization (IVF) procedures, primarily due to the high-dose hormonal stimulation protocols. These transient or sometimes persistent effects can include alterations in insulin sensitivity, transient hyperglycemia, and shifts in lipid profiles. Clinicians must recognize these changes to manage potential complications, particularly in women with pre-existing metabolic conditions like Polycystic Ovary Syndrome (PCOS).