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Isolevuglandins

Meaning

Isolevuglandins (IsoLGs) are highly reactive, aldehyde-containing lipid peroxidation products formed non-enzymatically from the free radical attack on polyunsaturated fatty acids, particularly docosahexaenoic acid (DHA). These compounds are clinically significant because they rapidly react with and covalently modify cellular proteins and DNA, serving as potent biomarkers and mediators of oxidative stress and chronic inflammation. Elevated levels of IsoLGs are a direct indicator of systemic cellular damage and are increasingly implicated in the pathology of age-related diseases and metabolic dysfunction, linking lipid health to hormonal signaling integrity.