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Isoallopregnanolone

Meaning

Isoallopregnanolone is a naturally occurring stereoisomer of the potent neurosteroid allopregnanolone, a metabolite of progesterone, distinguished by a subtle but critical difference in its molecular configuration. While its concentration in the central nervous system is typically lower than its allopregnanolone counterpart, it is recognized as an endogenous modulator of the GABA-A receptor, a primary inhibitory neurotransmitter receptor. The clinical significance of isoallopregnanolone lies in its potential role as a subtle regulator of mood, anxiety, and sleep architecture, contributing to the overall neuroendocrine milieu that influences psychological well-being. Its precise therapeutic profile is still under focused investigation.