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Irreversible Harm

Meaning

A clinical outcome or physiological change resulting from a therapeutic intervention or disease state that is permanent, non-remediable, and cannot be reversed by ceasing the intervention or through subsequent medical treatment. In the context of hormonal health, this may include permanent testicular atrophy from prolonged exogenous testosterone or severe cardiovascular damage. The concept underscores the critical need for meticulous risk-benefit analysis and informed consent in clinical decision-making.