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Iron Dysregulation

Meaning

Iron dysregulation describes any imbalance in the homeostatic control of iron metabolism within the body, encompassing both deficiency and overload states. Iron is a critical micronutrient required for oxygen transport, DNA synthesis, and cellular energy production, particularly in the thyroid and adrenal glands. Dysregulation, such as functional iron deficiency or pathological iron accumulation, impairs mitochondrial function and can directly compromise endocrine gland activity. Clinical assessment of this state requires evaluating multiple biomarkers, including ferritin, transferrin saturation, and C-reactive protein.