What is the Origin of Iron Bisglycinate Supplementation?

The origin lies in nutritional chemistry and pharmaceutical formulation, where the need for a better-tolerated and more absorbable iron compound led to the development of amino acid chelates. The term 'bisglycinate' precisely describes the molecular structure of this highly effective mineral complex.

What is the Mechanism of Iron Bisglycinate Supplementation?

Iron bisglycinate is absorbed intact in the small intestine via a mechanism that utilizes amino acid transporters, bypassing the conventional iron absorption pathway that is often saturated or inefficient. This mechanism avoids competition with other minerals and minimizes the free iron in the gut lumen, which typically causes oxidative stress and digestive upset. The enhanced uptake directly supports hemoglobin synthesis and iron storage.

Iron Bisglycinate Supplementation ∞ Area

Iron Bisglycinate Supplementation

Meaning

The clinical use of iron bisglycinate, a chelated form of iron where ferrous iron is bound to two molecules of the amino acid glycine, as a dietary supplement to correct or prevent iron deficiency. This specific chelate is favored in clinical practice due to its high bioavailability, superior absorption rate, and significantly reduced gastrointestinal side effects compared to traditional iron salts. It is a preferred method for restoring iron stores and serum ferritin levels.