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Ipamorelin Receptor Binding

Meaning

Ipamorelin receptor binding describes the specific molecular interaction where the synthetic pentapeptide Ipamorelin selectively attaches to and activates the ghrelin receptor, also known as the Growth Hormone Secretagogue Receptor type 1a (GHSR-1a). This binding event is the initiating step for Ipamorelin’s pharmacological action, leading to the pulsatile release of endogenous growth hormone (GH) from the anterior pituitary gland. The high specificity of this binding is clinically advantageous because it avoids activating receptors that typically lead to unwanted side effects, such as increased cortisol or prolactin release.