What is the Origin of Ipamorelin GHRP?

The term is a combination of the drug name "Ipamorelin" and the class designation "GHRP." It was developed through pharmaceutical research aimed at finding growth hormone secretagogues with improved safety profiles and specificity compared to earlier compounds. Its origin is rooted in the synthetic peptide chemistry of the late 20th century, seeking to harness the body's natural GH release mechanisms.

What is the Mechanism of Ipamorelin GHRP?

Ipamorelin's mechanism involves binding to the GHSR in the pituitary gland, mimicking the action of the endogenous hormone ghrelin. This binding triggers the release of GH from somatotroph cells. Crucially, its selective action avoids the concomitant rise in adrenocorticotropic hormone (ACTH), cortisol, and prolactin often seen with non-selective GHRPs, leading to a cleaner, more physiological GH pulse.

Ipamorelin GHRP

Meaning

Ipamorelin GHRP is a specific, selective Growth Hormone Releasing Peptide (GHRP) that functions as a potent secretagogue, stimulating the pituitary gland to release endogenous Growth Hormone (GH). This five-amino acid peptide is distinct from other GHRPs due to its high selectivity for the ghrelin/growth hormone secretagogue receptor (GHSR) and its characteristic lack of significant effect on prolactin or cortisol secretion. Clinically, it is used to restore more youthful, pulsatile GH secretion patterns, thereby enhancing anabolic drive and metabolic function.