Ipamorelin GH Secretagogue is a specific, synthetic pentapeptide that functions as a selective agonist of the Ghrelin receptor (GHS-R), stimulating the pituitary gland to release Growth Hormone (GH). As a secretagogue, it promotes the body’s natural GH production without significantly increasing levels of cortisol or prolactin, which can be side effects of some older GH-releasing peptides. Clinically, it is valued for its clean profile in promoting GH release to support muscle mass, fat loss, and tissue repair.
Origin
Ipamorelin was developed through pharmaceutical research aimed at creating Growth Hormone Secretagogues with improved selectivity and safety profiles compared to earlier compounds. Its designation as a ‘GH Secretagogue’ accurately reflects its mechanism of action: stimulating the secretion of an existing hormone rather than acting as a direct replacement. This peptide represents a refinement in the clinical approach to age-related GH decline.
Mechanism
The peptide mimics the action of the endogenous hormone Ghrelin, binding to the GHS-R in the anterior pituitary and the hypothalamus. This binding triggers a robust, natural-like pulse of GH release. The key mechanistic advantage is its high selectivity for the GH release pathway, minimizing the unwanted release of adrenocorticotropic hormone (ACTH), cortisol, and prolactin, thereby ensuring a more physiological and beneficial hormonal cascade.
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