A specific therapeutic regimen involving the combined administration of two synthetic peptides: Ipamorelin, a selective growth hormone secretagogue, and CJC-1295, a growth hormone-releasing hormone (GHRH) analog. This protocol is designed to synergistically stimulate the pulsatile, physiological release of endogenous Growth Hormone (GH) from the pituitary gland. It is a strategy employed in anti-aging and performance medicine to optimize body composition, cellular repair, and overall vitality without introducing exogenous GH.
Origin
The development of this protocol is rooted in decades of endocrinology research into the regulation of the somatotropic axis, the system controlling GH release. CJC-1295 was engineered for its long half-life due to its ability to bind to serum albumin, while Ipamorelin was developed for its high selectivity for the GH secretagogue receptor (GHSR) without significantly affecting cortisol or prolactin. Their combined use was established in clinical practice to maximize the physiological benefits of GH pulsatility.
Mechanism
The mechanism is dual-action and synergistic: CJC-1295 acts as a Growth Hormone-Releasing Hormone (GHRH) analog, binding to pituitary receptors to increase the number of somatotroph cells capable of releasing GH. Simultaneously, Ipamorelin, a ghrelin mimetic, binds to the GHSR, enhancing the amplitude of the GH pulse. This combined signaling mimics the body’s natural rhythm more effectively than single agents, resulting in a sustained, amplified release of GH, which then drives the production of Insulin-like Growth Factor 1 (IGF-1) in the liver, mediating the anabolic and regenerative effects.
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