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Ipamorelin Circadian Alignment

Meaning

Ipamorelin circadian alignment is the clinical practice of synchronizing the administration of the Growth Hormone Releasing Peptide (GHRP) Ipamorelin with the body’s natural 24-hour rhythm to maximize its physiological effect. This strategic timing is crucial because the pulsatile release of endogenous Growth Hormone (GH) is tightly regulated by the circadian clock, with the largest pulses occurring during deep sleep. Administering Ipamorelin, a selective GH secretagogue, in alignment with the natural deep sleep window optimizes the release of GH and subsequent Insulin-like Growth Factor-1 (IGF-1). The goal is to mimic the body’s youthful, physiological GH secretory pattern for enhanced restorative benefits.