What is the Origin of Invasive Breast Cancer Incidence?

This is a standard term in epidemiology and oncology, rooted in the systematic tracking of disease occurrence necessary for public health planning and identifying risk factors. The association with endocrinology became prominent with the discovery of hormone receptors on breast cancer cells and the subsequent development of endocrine therapies.

What is the Mechanism of Invasive Breast Cancer Incidence?

The incidence rate is influenced by the cumulative lifetime exposure of mammary tissue to circulating hormones. The mechanism often involves estrogen binding to its receptor (ER), which acts as a transcription factor to promote the growth and division of estrogen-sensitive cells. Other factors, such as progestin type and duration of exposure, also modulate this risk, highlighting the complex interplay between endogenous and exogenous hormones and cellular proliferation pathways.

Invasive Breast Cancer Incidence ∞ Area

Invasive Breast Cancer Incidence

Meaning

Invasive breast cancer incidence refers to the rate at which new cases of malignant tumors originating in the breast tissue and having breached the basement membrane are diagnosed within a defined population over a specified period. This epidemiological metric is a critical public health indicator. In hormonal health, the incidence rate is particularly relevant because sex steroids, notably estrogen and progesterone, are known to influence the proliferation and differentiation of mammary epithelial cells, thus modulating risk.