What is the Origin of Intrinsic Skin Aging?

The concept distinguishes the effects of internal biological clocks from environmental damage, separating chronological aging from photoaging. Research in gerontology and molecular dermatology established that cellular mechanisms, such as telomere shortening and decreased growth factor signaling, dictate this intrinsic trajectory. It highlights the role of inherent biology in the aging phenotype.

What is the Mechanism of Intrinsic Skin Aging?

The process involves a gradual reduction in the replicative capacity of fibroblasts and keratinocytes, leading to decreased production of structural proteins like collagen and elastin. Concurrently, reduced hormonal support, such as lower estrogen and growth hormone levels, diminishes the skin's regenerative capacity and moisture-retaining ability. The cumulative effect is atrophy and functional decline in the skin's layers.

Intrinsic Skin Aging ∞ Area

Intrinsic Skin Aging

Meaning

Intrinsic Skin Aging is the inevitable, genetically programmed process of skin deterioration that occurs independent of external environmental influences, driven by chronological time and endogenous physiological changes. This form of aging is characterized clinically by fine wrinkles, dryness, and a progressive thinning of the dermal layer. It reflects the fundamental biological processes of cellular senescence and hormonal decline.